L-O-Phosphoserine is a biomolecule that is used in combination with L-glutamine and vitamin B12 as a “roborant”—a restorative tonic—marketed under the trade names Vitasprint B12 and Fosforina B12. It is biosynthesized via the enzymatic phosphorylation of L-serine. F. C. Neuhaus and S. Korkes described the preparation of the racemic mixture in 1958. In 2011, C. J. Noren, J. Rinehart, and D. Söll developed a way to genetically encode L-O-phosphoserine anywhere in a protein sequence.
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