Phentermine, in combination with fenfluramine, formed the notorious appetite-suppressing drug Fen-Phen, which was withdrawn from the market in 1997 because it produced heart valve disease in two dozen patients. Before the development of Fen-Phen, phentermine was used as a cation-exchange resin complex in other diet drugs. It synthesis was first reported in 1946 by R. S. Shelton and M. G. Van Campen.
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