July 28, 2015
Image of Tetrahydrofuran 3D Image of Tetrahydrofuran

Tetrahydrofuran (THF, oxolane) is a versatile solvent used in laboratory organic synthesis and in industrial products such as varnishes. It is colorless and miscible in water, with a boiling point of 66 ºC. It is highly flammable but relatively nontoxic. When stored in air, it can form explosive peroxides, but this can be prevented by adding an inhibitor such as butylated hydroxytoluene (BHT).

In 1956, W. W. Gilbert and B. W. Howk at Du Pont patented the catalytic hydrogenation of maleic anhydride to produce THF. Du Pont later patented a process for hydrogenating furan to THF. Today the predominant THF manufacturing process is the acid-catalyzed dehydration of 1,4-butanediol. More than two dozen US patents on this process were issued between 1975 and 2007.

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