If we look at how the bark of the cinchona tree is used to treat malaria, we can see the cutting-edge chemistry of quinine binding an enzyme essential for the malaria parasite’s survival. But if we look from another angle, we can see how that coincidental affinity may have been a major contributing factor to World War I.
Sources:
- Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay
- Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
- The cellular thermal shift assay for evaluating drug target interactions in cells
- Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans
- Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
- Plasmodium falciparum purine nucleoside phosphorylase is critical for viability of malaria parasites
- Types of Malaria Parasites
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