Cimetidine is a competitive histamine H2-receptor antagonist that inhibits gastric acid secretion and reduces pepsin output. It was one of the first drugs discovered using a rational design method. G. J. Durant and co-workers reported its synthesis was reported in 1974. Cimetidine is the active ingredient in Tagamet and other "heartburn" drugs and has been used off-label to treat other medical conditions.
Learn more about this molecule from CAS, the most authoritative and comprehensive source for chemical information.
Stay Ahead of the Chemistry Curve
Learn how ACS can help you stay ahead in the world of chemistry.